sildenafil viagra skyline urology

What Do We Know about Generics?

Sildenafil means medications produced according to the same chemical composition as the original, Viagra, but by other pharmaceutical manufacturers. In order to make sure that the quality of generics is not worse than the originals’ one, it is important to pay much attention to companies manufacturing them. A big advantage of analogues is their moderate price along with the characteristics similar to the originals’ ones. Companies producing generics work with the ready formula and do not spend money on elaboration of the production process and advertising. Therefore, their prime cost is several-fold lower. Another advantage of generics is the diversity of their dosages and forms of presentation. Original medications are issued only in the form of tablets for peroral absorption. Viagra generics are distinguished by a great variety of dosages and presentation forms. Each man is able to choose the most convenient form individually.

Brand or Generic?

The effects of both brand and Generic Viagra are identical, and so are side effects, posology and taking instructions, dosing recommendations and safety information. The appearance, the name, the package and the price is what is different between Viagra and Generic Viagra. The generic drug, or equivalent, therefore contains the same active ingredient of the medicinal specialty from which it derives, and its name can refer exclusively to this active ingredient – in this case, sildenafil citrate.

On the other hand, a generic drug must demonstrate that it is bioequivalent to the branded drug: same therapeutic indications, same dose-effect ratio, same pharmaceutical form and administration route. Manufacturers must also ensure that generics meet the same quality requirements as the original drugs: the same purity, stability and a suitable final packaging.

If it complies with all these conditions, it is extremely unlikely that the generic will differ significantly in terms of efficacy and safety from the original. Therefore, preclinical drug reviews (such as animal studies) need not be repeated. It is also for this reason reduced experimental iter that equivalent drugs cost less; in particular, the Italian legislation establishes a price reduced for at least 20% for generic medicines compared to the corresponding reference medicine: a great saving both for patients and, in the case of reimbursable drugs, for the national health system.

How and Where to Buy Generic Viagra Safely?

Brand Name Viagra or Revatio
Generic Name Sildenafil or Generic Viagra
Time of Action 4 Hours
Indications Impotence (Erectile Dysfunction)
Doses 25mg, 50mg, 100mg
Prices $0.38 (Generic Tablet), $14 (Brand Tablet)
Where to Buy Online Safely? Canadian online pharmacy, U.S. Drugstores, Rx Services
Consult with specialist from Skyline Urology contact@urologyspecialtygroup.com or 239-256-1468

Sildenafil Applications

This medication is indicated for erectile dysfunction of any origin: physiological, psychological or mixed, and of any severity of disorder. Moreover, Sildenafil may be used for improvement of sexual intercourse quality and experiencing of new exciting feelings.

Route of Administration

Very often young men take 100 and 50 mg of this drug. This enables the maximally possible effect. Those who are going to try this medication for the first time should take 25mg. The dosage is indicative for elderly men and for those who suffer from chronic diseases. In severe cases of erectile dysfunction, the optimal dosage is 100mg. While meeting the requirements of Generic sildenafil usage, you may acquire a lot of unforgettable feelings during the sexual intercourse.

Sildenafil in Tablets

Tablets of Sildenafil or Generic Viagra are represented in maximum permissible for single-use dosage of 100mg. They are covered with coating. In the majority of cases the assigned dose makes 50mg (divide the tablet into two). If you suffer from either penis deformation, or severe disease of nephros and hepar, or cardiovascular disease, the intake of tablets must be reduced to the dosage of 25mg. This form of Sildenafil will provide perfect results. You may count on excellent erection, continuous sexual intercourse, exciting feelings and long-lasting orgasm. Sensations and orgasm become enhanced because the drug causes sensitivity of genitals. The medication is to be taken once per day.

Sildenafil in Capsules

Capsules of Sildenafil contain the dosage of 100mg. This remedy is issued in the form of gelatin capsules packed in blisters. While penetrating into blood, sildenafil citrate inhibits the operation of phosphodiesterase type 5 inhibitors which is concentrated in penis tissues. As a result, a concentration of cyclic guanosine monophosphate in the tissues of cavernous bodies relaxing their cells and increasing blood supply to them starts growing. This process causes erection. This is exactly nitrogen oxide which launches the chain of all above mentioned chemical reactions. Liberation of nitrogen oxide by nerve terminals starts only in case of sexual arousal and is impossible without it.

Sildenafil Gel

One package of Sildenafil gel contains 100mg of sildenafil with pleasing savour. This is a maximal daily dose of medication. In case this quantity of active substance is too big for you, take only a half of the bag. As a result of sildenafil’s action the unstriated muscles of penis relax, vessels enlarge and blood circulation activates. Sexual stimulation and arousal cause the filling of penis with blood and occurrence of steady erection. If you suffer from either penis deformation, or severe disease of nephros and hepar, or cardiovascular disease, the intake of gel must be reduced to the dosage of 25mg (to ¼ of bag). Sildenafil gel is dedicated for erectile dysfunction treatment for any etiology and for men at any age.

Sildenafil Jellies (Chewable Pills)

These forms of Sildenafil are dedicated for sucking and chewing. Their main advantage consists in shirt interim between the intake and onset of action. It is recommended to use jellies if you do not tolerate treatment with pills. Moreover, sucking and chewing pills with pleasing savour do not resemble therapy. Their intake will cause only pleasure. Sildenafil jellies should be taken in dosage of 100mg. If you haven’t taken any medications for erectile dysfunction, it is better to start with ½ pill (50mg). Maximal daily dose is 1 pill.

Major Comparison of Tablets, Capsules, Gel and Jellies

Onset time

The onset time of various product forms is different; therefore, they should be taken in such a way that the required effect occurred timely. Thus, the tablets should be taken one hour before sexual intercourse, gel and jellies – 10-15 minutes, capsules – 20-30 minutes before this. Anyway, it is necessary to remember that it is prohibited to reduce the interim between intakes. It must be not less than 24 hours.

Let us consider this topic in greater detail:

  • For tablets, it takes 40-60 minutes to be absorbed into blood. Sildenafil enhances blood supply to penis and causes erection. After the ending of sexual intercourse, a penis returns to its relaxed condition, the only difference being that the recovery period is a bit shorter than the common sexual intercourse.
  • Capsules should be taken under fasting conditions around 30 minutes prior to sexual intercourse. The intake after food interrupts absorption of active substance and its effect may either not develop or become very weak. Do not combine sildenafil with alcoholic drinks causing dangerous arterial blood pressure drop and do not wash it off with grapefruit juice which may change the work of liver enzymes and result in overdose of sildenafil citrate and subsequent enhanced side-effects. Capsules start coming into action in 15 minutes.
  • Gel may be taken right from bags where the medication is packed or diluted in non-alcoholic beverages and drunk 10-15 minutes before sexual intercourse. You must not combine the intake of Sildenafil gel with alcohol. It is possible to have a non-substantial meal before its intake. In accordance with the existing dosage a bag may be divided into portions. The interim between intakes should be not less than 24 hours.
  • Jellies should be taken 30-45 minutes before the expected sexual intercourse with a lot of water. These product forms come to action in 15-20 minutes. Hearty meal may slow down the occurrence of the effect considerably. After the intake coitus is possible within 4-5 hours.

Effect Duration

  • The effect of tablets lasts 4-5 hours. Sexual intercourse becomes not only more qualitative, but also long-lasting.
  • Capsules keep their effect for 4 hours. Their effect is headlong thanks to the fact that the active substance of capsules is in jelly-like condition. It is placed into a gelatin capsule which after the intake is absorbed much faster than usual tablets.
  • The huge advantage of gel is its fast onset time and long-lasting effect duration. It takes only ten minutes from the intake to the occurrence of action. Such a speed is explained by the consistency of jelly which is absorbed into tiny capillaries right in the mouth cavity. The substance is less affected by digestive juice and food. Therefore, substantial food doesn’t reduce its action. The effect lasts up to 6 hours. Those who dislike tablets will be pleased to try a gel form. It has a savory flavor and looks more like a dessert than a medicine.
  • Jellies continue their action within 3-4 hours. In comparison with other medication forms of Generic sildenafil, this is the least effective duration. But it is quite enough to experience wonderful sexual intercourse.

Individual Preferences

  1. Nowadays jellies are the most popular product form of Sildenafil among others. Its high efficiency along with reasonable price makes this analogue become requisitioned. Jellies’ action is very fast; therefore, it may be taken even by people suffering from peptic ulcer.
  2. The most long-running form of Sildenafil is gel lasting 6 hours. Its pleasant fruit flavor and capability to get absorbed in the mouth cavity within 10 minutes makes it a perfect remedy for those who cannot or don’t like to take tablets.
  3. Capsules also have a perfect absorption period (much faster than the one of tablets) and duration of effect. Although for those who need to divide a capsule into two, it is rather problematic.
  4. The most usual form of Sildenafil is tablets. They will be useful for those who do not want to experiment and choose the most well-tried variants.

Safety Information of Generic Viagra

It is absolutely contraindicated to take Generic Viagra for all those with serious cardiovascular disorders, and in particular:

  • Patients with unstable angina or who have had episodes of angina during sexual intercourse;
  • Patients who have had heart failure in the last 6 months;
  • Patients with uncontrolled arrhythmias, hypotension (<90/50 mm Hg) or uncontrolled hypertension;
  • Patients who have had a cerebrovascular episode in the last 6 months;
  • Patients who have lost their eyesight due to non-arteritic anterior ischemic optic neuropathy (NAION).

If the side effects on an organic level are very well known, those on a psychological and neurophysiological level are much less. The abuse of Generic Viagra can lead to addiction but also to forms of dysregulation of the neurovegetative system. It is good to know that Generic Viagra is not 100% effective. To function it needs emotional involvement and sexual desire. If the cause is not organic but psychological, as is the very common performance anxiety, the drug will not be sufficient to solve the problem but will act as a placebo (reassuring) effect. The serenity and the safety that the drug, in the case of a good outcome of the relationship, will spread in the patient, will initiate mechanisms of abuse and dependence difficult, subsequently, to be eradicated.

The intake of ED drugs (with the exception of Cialis and the latest generation of drugs that are continuous coverage) leads to a real planning of sexual intercourse (about an hour earlier) with consequent reduction of spontaneity and harmony of the couple.

Imagine for a moment that you move from the room to the kitchen. Imagine sitting down at the table, seeing in front of you some cooked food without feeling the slightest appetite, but having to eat only on the fact that everyone does it and it is good that you do too. Imagine now that there is a drug that makes you hungry, dilating your stomach, even in the absence of appetite. If you feel a sense of disgust, it’s about what happens to some people with sex. The more we have sex without a real ‘appetite’ the less we taste and the less we will enjoy it.

Neuroscience tells us that what we think and feel on an emotional and bodily level in the present moment is very important. Drugs like Generic Viagra can reinforce a dysfunctional view of sex as a challenge beyond oneself and one’s own feelings, rather than a real encounter and exchange of pleasure with each other. The risk is that over time there remains only the pleasure of winning another challenge with ourselves, or worse, the fear that the next time we will not make it.

The human organism has its own complexity of functioning so it must take into account both organic and psychological variables. In the face of these complexities, it is good to do them without using shortcuts and simplifications. Failure to listen to our emotions can lead to a series of side effects, first of all a dysregulation of the neurovegetative system and the recurrence, after some time, of the erection deficit no longer able to respond to the drug, or a deterioration of sexual desire and / or the appearance of an orgasm disorder (such as premature ejaculation, delayed orgasm or anorgasmia).

That said, it does not mean that these drugs should not be used, but their prescription only needs to be done under specific clinical conditions and especially under the supervision of a primary care physician and a clinical sexologist.

Side-Effects

Following the use of Generic Viagra:

  • At 14.5% of patients, headache occurs;
  • 3% headache and abdominal pain;
  • 4-5% hot flashes and abdominal pain;
  • At 2.3% vertigo.