Malegra FXT (Sildenafil Citrate with Fluoxetine 100/40mg)

Malegra FXT is a pharmacological product designed to treat sexual health illnesses in men. Its dual-action formulation works effectively against erectile dysfunction (ED) and premature ejaculation (PE), two conditions often found challenging to treat concurrently. This article sheds light on various aspects of Malegra FXT, making its understanding accessible to all.

How Does It Work?

Malegra FXT is a drug that combines two active ingredients: Sildenafil Citrate and Fluoxetine. This pharmaceutical compound addresses two prevalent male sexual concerns, namely erectile dysfunction (ED) and premature ejaculation (PE).

Here is how it works:

Sildenafil Citrate: This component is a phosphodiesterase type 5 (PDE5) inhibitor. When a man is sexually stimulated, nitric oxide is released into the penis. The liberation of nitric oxide initiates the generation of cyclic guanosine monophosphate (cGMP), an element that fosters the relaxation of the smooth muscular tissues encompassing the penile vicinity. This relaxation, in turn, facilitates enhanced blood circulation. However, PDE5 can break down cGMP, reducing its effect. Sildenafil Citrate inhibits PDE5, thus maintaining high levels of cGMP, promoting increased blood flow into the penis, and aiding in achieving and maintaining an erection.

Fluoxetine, an agent classified as a discerning inhibitor of serotonin reuptake (SSRI), is conventionally employed in treating depressive disorders, anxiety-related ailments, and the intricacies of obsessive-compulsive pathology. However, it’s included in Malegra FXT due to its side effect of delaying ejaculation. Its mechanism of action involves augmenting serotonin levels, a vital neurotransmitter, within the intricate framework of the brain. It, in turn, slows the reflex that triggers ejaculation, helping men with PE to have more control over ejaculation.

It’s important to note that Malegra FXT does not induce sexual arousal; it aids in the physiological processes that enable an erection and delay ejaculation when arousal occurs naturally. Furthermore, akin to the entire spectrum of pharmaceuticals, it is imperative that this substance be administered in strict accordance with the guidance of a qualified healthcare professional, for its utilization may potentially induce adverse reactions and provoke intricate interplays with other compounds. It is of utmost importance to acknowledge that this medication may not be suitable for every individual, as certain persons with specific medical conditions or those concurrently undergoing treatment with other pharmaceutical agents may encounter contraindications preventing its safe and effective use.

How to Use Malegra FXT?

Malegra FXT is an oral remedy, and here are general guidelines for its use:

Dosage: Generally, the medicine should be taken once per day. However, your doc will determine the specific dosage and frequency based on your health condition, response to treatment, and other remedies you may be taking.

Timing: It’s typically recommended to take Malegra FXT about an hour before sexual activity. However, it can be taken anywhere from 30 minutes to 4 hours before sexual activity.

Consumption: Swallow the tablet whole with a glass of water. It can be taken with or without food, but remember that having it with a high-fat meal may delay when the medicine starts to work.

Limitations: Take up to one dose per day. Overdosing can increase the risk of adverse outcomes.

Potential Side Effects

Malegra FXT, like any drug, can have potential adverse outcomes due to its active ingredients — Sildenafil Citrate and Fluoxetine. Although not all individuals encounter these accompanying manifestations, it remains crucial to maintain a vigilant awareness regarding their potential occurrence. Here are some of the possible adverse outcomes:

Common Side Effects:

  • Headache
  • Dizziness
  • Flushing (warmth, redness, or tingly feeling)
  • Upset stomach or indigestion
  • Nasal congestion
  • Back pain
  • Nausea
  • Sleep problems (insomnia)
  • Dry mouth
  • Decreased libido or sexual ability

Serious Side Effects:

  • Vision changes or sudden vision loss
  • Ringing in your ears or sudden hearing loss
  • Chest pain or pressure, pain spreading to your jaw or shoulder
  • Irregular heartbeat
  • Swelling in your hands, ankles, or feet
  • Shortness of breath
  • Seizures (convulsions)
  • A light-headed feeling, like you might pass out
  • An erection that is painful or lasts longer than 4 hours (prolonged erection can damage the penis)

It is a partial list of side effects, and others may occur. Contact your doc immediately if you experience any adverse consequences, even those not listed, or have concerns. Serious adverse outcomes are rare, but they require immediate medical attention.

Precautions and Contraindications

When using Malegra FXT, several precautions and contraindications should be kept in mind to ensure safety:


Medical History: Before using Malegra FXT, inform your doc about your medical history, especially if you have heart concerns (such as heart attack or life-threatening irregular heartbeat in the past six months, chest pain/angina, heart failure), stroke in the past six months, kidney disease, liver disease, high or low arterial pressure, severe dehydration, penis conditions (such as angulation, fibrosis/scarring, Peyronie’s disease), history of painful/prolonged erection (priapism), conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma), eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION).

Alcohol: The consumption of alcoholic beverages can elevate the probability of experiencing untoward consequences, including sensations of dizziness and lightheadedness. Limit your alcohol consumption when using this remedy.

Activities Requiring Alertness: This drug can cause dizziness or affect your vision. Only drive, use machinery, or do any activity that requires alertness or clear vision once you can safely perform such activities.


Nitrate Remedy: If you take any nitrate drug (used for chest pain), you should not take Malegra FXT. This combination can cause a severe decrease in arterial pressure.

Allergy: If you have a known sensitivity or allergic response to Sildenafil, Fluoxetine, or any of the inactive constituents contained within this medication, it is crucial to abstain from its utilization.

Heart Conditions: Those with unbearable heart conditions or who have had a recent heart attack or stroke should not use this drug without discussing it with their healthcare provider.

Liver or Kidney Disease: Those with severe liver or kidney disease should use this remedy with caution and under the guidance of a healthcare provider, as they may need a dose adjustment.

Women and Children: This remedy is not specified for use by females and youngsters.

How to Store

Roper storage of Malegra FXT is essential to maintain its effectiveness. Here are some guidelines:

Temperature: Store the medicine at room temperature, between 20 to 25 degrees Celsius (68 to 77 degrees Fahrenheit).

Light and Moisture: Keep the drug away from sun rays and moistness. Henceforth, refrain from stowing the aforementioned substance within the confines of a lavatory and diligently ensure its placement in an area devoid of direct exposure to the sun’s radiant rays.

Out of Reach: Store it out of the reach of children and pets.

Container: Keep the medicine in its original packaging until it’s time to take it.

Expiration: Wait to use the medicine past its expiry date. Dispose of any unused or expired drugs properly.

Pharmaceuticals that Shouldn’t be Combined with Malegra FXT

Several medicines can interrelate with Malegra FXT (Sildenafil Citrate and Fluoxetine), causing potentially serious outcomes.

Here are some classes of drugs that may interrelate with Malegra FXT:

  • Nitrate Drugs are typically used for chest pain or heart conditions. Nitrate drugs combined with Sildenafil can cause a severe and sudden decrease in arterial pressure. Instances of such drugs encompass nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.
  • Alpha-Blockers: Used for treating high arterial pressure or an enlarged prostate. Examples include doxazosin and tamsulosin. These drugs, when taken with Sildenafil, can also lead to a considerable drop in arterial pressure.
  • Other Erectile Dysfunction Drugs: Taking Malegra FXT with other ED prescriptions can increase the risk of adverse outcomes. Examples include tadalafil (Cialis) and vardenafil (Levitra).
  • Certain Antibiotics and Antifungals: Certain antibiotics and antifungal medications can modify the metabolic processes of Sildenafil and Fluoxetine within your body, potentially resulting in heightened adverse effects.
  • HIV Protease Inhibitors: These drugs for treating HIV can also influence how your body processes Sildenafil and Fluoxetine. Examples include ritonavir and saquinavir.
  • Certain Antidepressants: As Malegra FXT already contains an antidepressant (Fluoxetine), it can interrelate with other antidepressants leading to an increase in serotonin levels, resulting in a condition called serotonin syndrome.
  • Drugs that Affect Bleeding: Combining Malegra FXT with drugs that affect bleeding (like warfarin, NSAIDs) may increase the risk of bleeding.

Always remember that while Malegra FXT can assist with the physiological aspects of erectile dysfunction and premature ejaculation, it does not replace the need for open communication and mutual consent in a sexual relationship or protect against sexually transmitted diseases. Order Malegra FXT from an online Canadian pharmacy to enjoy prompt shipping of a superior product at an affordable price.


The content provided here is meant solely for educational purposes and should not be considered as medical advice. It is important to seek the guidance of a healthcare professional before starting, stopping, or altering any medication or treatment plan. Using this information is done at your own discretion and the author and publisher cannot be held responsible for any negative consequences that may occur as a result.